Enzymatic phosphorylation of macrolide antibiotics.
نویسندگان
چکیده
Five macrolide antibiotics (erythromycin A, 1; oleandomycin, 3a; tylosin, 4a; spiramycins, 5a; leucomycin A3, 6a) have been phosphorylated enzymatically using cell-free extracts derived from Streptomyces coelicolor UC 5240. The necessary cofactors and the rates of the conversion have been determined.
منابع مشابه
Microbial O-phosphorylation of macrolide antibiotics.
Crude enzymepreparations of Streptomyces coelicolor (Miiller), UC 5240 in the presence of ATP and Mg2+ catalyzed the conversion of oleandomycin, tylosin, leucomycin A3 and a mixture of spiramycins I, II and III to their antibiotically inactive I'-O-phosphates.10 Under identical conditions, erythromycin was converted to anhydroerythromycin-Z'-O-phosphate.10 As O-phosphorylation of aminocyclitols...
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عنوان ژورنال:
- The Journal of antibiotics
دوره 40 2 شماره
صفحات -
تاریخ انتشار 1987